Hypoxia suppresses kainate-induced gamma-oscillations in rat hippocampal slices.
Neuroreport
; 18(17): 1827-31, 2007 Nov 19.
Article
en En
| MEDLINE
| ID: mdl-18090320
ABSTRACT
Hypoxia or global ischemia causes rapid loss of consciousness and a sudden increase in spontaneous transmitter release suggesting that coordinated synaptic activity is impaired. Gamma oscillations (30-100 Hz) are thought to provide for binding of parallel processed information in the brain, contributing to cognition and formation of short-term memory. We hypothesized that gamma-oscillations are rapidly blocked by hypoxia and that prolonged hypoxia reduces the capability to generate such activity. In ventral hippocampal slices, kainate-induced gamma-oscillations reversibly declined 40 s after onset of 3 min hypoxia. Repetition of such hypoxic periods led to accumulative impairment of gamma-activities. By contrast, 6 min of hypoxia led to a transient anoxic depolarization after which gamma-oscillations remained almost completely blocked.
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Bases de datos:
MEDLINE
Asunto principal:
Hipoxia Encefálica
/
Agonistas de Aminoácidos Excitadores
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Electroencefalografía
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Hipocampo
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Ácido Kaínico
Límite:
Animals
Idioma:
En
Revista:
Neuroreport
Asunto de la revista:
NEUROLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Alemania