Evaluation of engraftment after single islet transplantation from a brain-dead donor by the secretory unit of islet transplant objects (SUITO) index.
Transplant Proc
; 40(2): 364-6, 2008 Mar.
Article
en En
| MEDLINE
| ID: mdl-18374069
ABSTRACT
BACKGROUND:
Evaluation of engraftment is important to assess the success of islet transplantation. Recently, we developed a simple index of islet engraftment, the secretory unit of islet transplant objects (SUITO) index. The formula is 1500 x fasting C-peptide level [ng/dL]/(fasting blood glucose levels [mg/dL]-63). A SUITO index of more than 26 was associated with insulin independence. MATERIALS ANDMETHODS:
In this study, we compared islet engraftment efficacy using the SUITO index after a single infusion of islets from brain-dead donors into 6 recipients. We calculated the SUITO index from postoperative days 3 to 30. We compared the insulin reduction rate with the SUITO index and islet equivalent per kilogram body weight (IE/Kg). We also measured the level of glycosylated hemoglobin (HbA 1C) at 3 months posttransplantation to assess glycemic control after islet transplantation.RESULTS:
In 5 cases, islets were cultured before transplantation and in 1 case they were transplanted without culture. Without culture, the SUITO index and insulin reduction rate were highest. The SUITO index significantly correlated with the insulin reduction rate (P = .031, R2 = .728), but the IE/kg was not significantly correlated (P = .303) with the rate of insulin reduction. All cases showed improved HbA 1C to the normal range.CONCLUSIONS:
Immediate transplantation without culture substantially improved the efficacy of engraftment of transplanted islets. The SUITO index was a better predictor than islet mass per body weight for clinical outcomes.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Donantes de Tejidos
/
Muerte Encefálica
/
Trasplante de Islotes Pancreáticos
/
Selección de Paciente
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Transplant Proc
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos