Activation of the calcium sensing receptor stimulates gastrin and gastric acid secretion in healthy participants.
Osteoporos Int
; 20(1): 71-8, 2009 Jan.
Article
en En
| MEDLINE
| ID: mdl-18536954
ABSTRACT
UNLABELLED In 17 adults on a fixed metabolic diet, an 11-day course of cinacalcet increased serum gastrin and basal gastric acid output, but not maximal gastric acid output, compared with a placebo. These findings indicate that the calcium sensor receptor plays a role in the regulation of gastric acid. INTRODUCTION:
Gastric acid secretion is a complex process regulated by neuronal and hormonal pathways. Ex vivo studies in human gastric tissues indicate that the calcium sensing receptor (CaR), expressed on the surface of G and parietal cells, may be involved in this regulation. We sought to determine whether cinacalcet, a CaR allosteric agonist, increases serum gastrin and gastric acid secretion.METHODS:
Seventeen healthy adults with normal gastric acid output were placed on an 18-day metabolic diet. On day 8 (baseline), participants were given cinacalcet (15 then 30 mg/day) or placebo for 11 days. Changes in gastric acid output, serum gastrin, and other measures were compared in the two groups.RESULTS:
Changes in serum gastrin and basal acid output (adjusted for baseline body weight) were significantly more positive in the cinacalcet group compared with placebo (P = 0.004 and P = 0.039 respectively). Change in maximal acid output was similar in the two groups (P = 0.995). As expected, cinacalcet produced significant decreases in serum PTH (P < 0.001) and ionized calcium levels (P = 0.032), and increases in serum phosphorus levels (P = 0.001) and urinary calcium (P = 0.023).CONCLUSIONS:
This study provides in vivo evidence that activation of the CaR increases serum gastrin levels and basal gastric acid secretion in healthy adults.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Gastrinas
/
Receptores Sensibles al Calcio
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Ácido Gástrico
/
Mucosa Gástrica
/
Naftalenos
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Osteoporos Int
Asunto de la revista:
METABOLISMO
/
ORTOPEDIA
Año:
2009
Tipo del documento:
Article