Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale.
Methods Find Exp Clin Pharmacol
; 30(3): 225-30, 2008 Apr.
Article
en En
| MEDLINE
| ID: mdl-18597008
ABSTRACT
Sedation is the most frequent side effect of H(1)-antihistamines, and, sometimes, it may be life-threatening for patients. Evaluation of the sedative properties of H(1)-antihistamines is important to improve the patients' quality of life (QOL). Therefore, we carried out a large-scale surveillance quantified through a questionnaire using visual analog scale (VAS) from 1,742 patients. The results showed that the degree of sleepiness caused by some nonsedative second-generation antihistamines, including fexofenadine, olopatadine and cetirizine, was disease dependent. In atopic dermatitis, an unexpectedly low VAS score of sleepiness was obtained for the first-generation antihistamine d-chlorpheniramine, which is similar to those obtained for bepotastine and epinastine. d-Chlorpheniramine also showed a high VAS score in efficacy. Meanwhile, fexofenadine showed a higher VAS score of sleepiness in atopic dermatitis than those obtained in the other allergic diseases including allergic rhinitis, urticaria and asthma. In asthma, a higher VAS score of sleepiness was found for olopatadine, ebastine and cetirizine, when compared with d-chlorpheniramine. On the other hand, bepotastine showed the lowest VAS score for sleepiness. Our findings suggest the existence of unknown factors influencing the sedative properties of H(1)-antihistamines. Therefore, appropriate H(1)-antihistamines may need to be selected, depending on allergic diseases, to improve patients' QOL.
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Bases de datos:
MEDLINE
Asunto principal:
Fases del Sueño
/
Dimensión del Dolor
/
Vigilancia de la Población
/
Antagonistas de los Receptores Histamínicos H1
Tipo de estudio:
Screening_studies
Límite:
Aged80
País/Región como asunto:
Asia
Idioma:
En
Revista:
Methods Find Exp Clin Pharmacol
Año:
2008
Tipo del documento:
Article
País de afiliación:
Japón