Hepatectomy for hepatocellular carcinoma patients who meet the Milan criteria.
Hepatogastroenterology
; 55(82-83): 621-6, 2008.
Article
en En
| MEDLINE
| ID: mdl-18613420
ABSTRACT
BACKGROUND/AIMS:
Although hepatocellular carcinoma patients who meet the Milan criteria are optimal candidates for liver transplantation, most such patients in Japan have been treated without liver transplantation.METHODOLOGY:
In this retrospective analysis, the patient selection criteria were (1) admission between 1992 and 2005, (2) fulfillment of the Milan criteria, (3) classification within the Barcelona Clinic Liver Cancer stages A1-A4, and (4) no previous anticancer treatment.RESULTS:
Of 451 patients who met the selection criteria, 162 underwent hepatectomy. The proportion of patients who underwent hepatectomy was 58% of 106 with stage A1 and 29% of 345 with stages A2-A4. For patients with stages A2-A4, the survival probability after hepatectomy at 3, 5, and 7 years was 89%, 70%, and 61%, respectively. There were no significant differences in survival time between stages A1 and stages A2-A4 after hepatectomy. Among patients with Child-Pugh scores of 5 and 6 in stages A2-A4, 51% and 29% underwent hepatectomy, respectively.CONCLUSIONS:
Hepatectomy may be an appropriate first-line treatment option for patients with stages A2-A4 who meet the Milan criteria, when they have a good hepatic reserve and a long waiting time for liver transplantation.
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Bases de datos:
MEDLINE
Asunto principal:
Carcinoma Hepatocelular
/
Hepatectomía
/
Neoplasias Hepáticas
Tipo de estudio:
Observational_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Hepatogastroenterology
Año:
2008
Tipo del documento:
Article
País de afiliación:
Japón