High-activity variants of the uMAOA polymorphism increase the risk for depression in a large primary care sample.
Am J Med Genet B Neuropsychiatr Genet
; 150B(3): 395-402, 2009 Apr 05.
Article
en En
| MEDLINE
| ID: mdl-18626920
ABSTRACT
Studies on the association between the functional uMAOA polymorphism and depression have yielded non-conclusive results up till now. One thousand two hundred twenty eight consecutive Spanish primary care attendees, participating in the PREDICT study, agreed to take part in this genetic PREDICT-Gene study. We explored the association between depression and either high-activity uMAOA alleles or genotypes. Depression was diagnosed using the Composite International Diagnostic Interview (CIDI) to establish three different depressive outcomes (ICD-10 Depressive Episode (DE), ICD-10 Severe Depressive Episode (SDE) and DSM-IV Major Depression (MD)). uMAOA genetic variation was determined by PCR amplification and subsequent electrophoresis. Crude and adjusted (gender and/or age) odds ratios, with 95% confidence intervals, were calculated for the associations between allele or genotype frequencies and all three depressive outcomes. We found associations between all three depressive phenotypes and either high-activity alleles or high-activity genotypes in both sexes. The associations were statistically significant for females but not for males. Testing the same associations on the entire sample (males and females) also yielded significant associations between depression and either high-activity alleles or high-activity genotype distribution that were independent of age and/or gender (ICD-10 DE OR = 1.98; 95% CI 1.42-1.77; P = 0.00002; ICD-10-SDE OR = 2.05; 95% CI 1.38-3.05; P = 0.0002; DSM-IV MD OR = 1.91; 95% CI (1.26-2.91); P = 0.0014). Our results provide fairly consistent evidence that high-activity variants of the MAOA promoter polymorphism confer a modestly higher risk for depression.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
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Atención Primaria de Salud
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Variación Genética
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Depresión
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Monoaminooxidasa
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Am J Med Genet B Neuropsychiatr Genet
Asunto de la revista:
GENETICA MEDICA
/
NEUROLOGIA
/
PSIQUIATRIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
España