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Identification of loci associated with schizophrenia by genome-wide association and follow-up.
O'Donovan, Michael C; Craddock, Nicholas; Norton, Nadine; Williams, Hywel; Peirce, Timothy; Moskvina, Valentina; Nikolov, Ivan; Hamshere, Marian; Carroll, Liam; Georgieva, Lyudmila; Dwyer, Sarah; Holmans, Peter; Marchini, Jonathan L; Spencer, Chris C A; Howie, Bryan; Leung, Hin-Tak; Hartmann, Annette M; Möller, Hans-Jürgen; Morris, Derek W; Shi, Yongyong; Feng, GuoYin; Hoffmann, Per; Propping, Peter; Vasilescu, Catalina; Maier, Wolfgang; Rietschel, Marcella; Zammit, Stanley; Schumacher, Johannes; Quinn, Emma M; Schulze, Thomas G; Williams, Nigel M; Giegling, Ina; Iwata, Nakao; Ikeda, Masashi; Darvasi, Ariel; Shifman, Sagiv; He, Lin; Duan, Jubao; Sanders, Alan R; Levinson, Douglas F; Gejman, Pablo V; Cichon, Sven; Nöthen, Markus M; Gill, Michael; Corvin, Aiden; Rujescu, Dan; Kirov, George; Owen, Michael J; Buccola, Nancy G; Mowry, Bryan J.
Afiliación
  • O'Donovan MC; Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK. wpcmod@cf.ac.uk
Nat Genet ; 40(9): 1053-5, 2008 Sep.
Article en En | MEDLINE | ID: mdl-18677311
ABSTRACT
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P = 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Esquizofrenia / Predisposición Genética a la Enfermedad / Factores de Transcripción de Tipo Kruppel / Estudio de Asociación del Genoma Completo Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2008 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Esquizofrenia / Predisposición Genética a la Enfermedad / Factores de Transcripción de Tipo Kruppel / Estudio de Asociación del Genoma Completo Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2008 Tipo del documento: Article País de afiliación: Reino Unido