Optimization of a series of potent and selective ketone histone deacetylase inhibitors.
Bioorg Med Chem Lett
; 18(20): 5528-32, 2008 Oct 15.
Article
en En
| MEDLINE
| ID: mdl-18809328
ABSTRACT
Histone deacetylase (HDAC) inhibitors offer a promising strategy for cancer therapy and the first generation HDAC inhibitors are currently in the clinic. Herein we describe the optimization of a series of ketone small molecule HDAC inhibitors leading to potent and selective class I HDAC inhibitors with good dog PK.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Inhibidores Enzimáticos
/
Inhibidores de Histona Desacetilasas
/
Histona Desacetilasas
/
Cetonas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Italia