Ileal mucosal and fecal pancreatitis associated protein levels reflect severity of salmonella infection in rats.
Dig Dis Sci
; 54(12): 2588-97, 2009 Dec.
Article
en En
| MEDLINE
| ID: mdl-19160051
ABSTRACT
BACKGROUND:
Microbial infections induce ileal pancreatitis-associated protein/regenerating gene III (PAP/RegIII) mRNA expression. Despite increasing interest, little is known about the PAP/RegIII protein. Therefore, ileal mucosal PAP/RegIII protein expression, localization, and fecal excretion were studied in rats upon Salmonella infection.RESULTS:
Salmonella infection increased ileal mucosal PAP/RegIII protein levels in enterocytes located at the crypt-villus junction. Increased colonization and translocation of Salmonella was associated with higher ileal mucosal PAP/RegIII levels and secretion of this protein in feces.CONCLUSIONS:
PAP/RegIII protein is increased in enterocytes of the ileal mucosa during Salmonella infection and is associated with infection severity. PAP/RegIII is excreted in feces and might be used as a new and non-invasive infection marker.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Salmonella enteritidis
/
Salmonelosis Animal
/
Biomarcadores de Tumor
/
Lectinas Tipo C
/
Heces
/
Íleon
/
Antígenos de Neoplasias
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Dig Dis Sci
Año:
2009
Tipo del documento:
Article
País de afiliación:
Países Bajos