Cellular and molecular mechanisms of memory T-cell survival.
Expert Rev Vaccines
; 8(3): 299-312, 2009 Mar.
Article
en En
| MEDLINE
| ID: mdl-19249972
ABSTRACT
Long-term maintenance of the memory T-cell response is the hallmark of immune protection and, hence, constitutes one of the most important objectives of vaccine-development strategies. Persistent memory T cells, developed after vaccination or microbial infections, ensure the generation of an antimicrobial response upon re-exposure to the pathogen through rapid clonal proliferation and activation of effector functions. However, in the context of many pathogen infections, these memory T cells fail to persist and die. In this review, we will highlight recent exciting findings in studies of memory T cells, their generation, their lineage relationships and their survival pathways; indeed, survival of memory T cells and maintenance of their functionality are key features of the immune response in its quest to control disease progression and in the development of vaccines to persistent microbial infections.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Memoria Inmunológica
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Expert Rev Vaccines
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Canadá