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Regression of melanoma metastases following treatment with the n-bisphosphonate zoledronate and localised radiotherapy.
Laggner, U; Lopez, J S; Perera, G; Warbey, V S; Sita-Lumsden, A; O'Doherty, M J; Hayday, A; Harries, M; Nestle, F O.
Afiliación
  • Laggner U; St John's Institute of Dermatology, King's College London, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.
Clin Immunol ; 131(3): 367-73, 2009 Jun.
Article en En | MEDLINE | ID: mdl-19250873
We report a case of regression of pulmonary and bony metastases in a patient with malignant melanoma following palliative treatment with systemic zoledronate and localised radiotherapy to the bone. Zoledronate is a potent new bisphosphonate used for the treatment of metabolic bone diseases including bone metastases due to its inhibitory effect on osteoclasts. In the context of metastatic cancer zoledronate is routinely used to improve bone pain and reduce the frequency of skeletal events. There is also an increasing body of evidence suggesting that bisphosphonates exhibit anti-tumour properties. Bisphosphonates are able to activate Vgamma9Vdelta2 gamma-delta T cells which can be key players in the immune defence against malignant cells. Furthermore bisphosphonates have direct anti-proliferative, anti-metastatic and pro-apoptotic effects on tumour cells. These actions, together with their low side effect profile, may prove to be useful therapeutic tools in the treatment of cancer even in the absence of bone metastases. On the basis of this case report we here review the current literature on present preclinical and clinical studies using bisphosphonates for the treatment of cancer.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Óseas / Difosfonatos / Imidazoles / Neoplasias Pulmonares / Melanoma Límite: Female / Humans / Middle aged Idioma: En Revista: Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2009 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Óseas / Difosfonatos / Imidazoles / Neoplasias Pulmonares / Melanoma Límite: Female / Humans / Middle aged Idioma: En Revista: Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2009 Tipo del documento: Article