Human gastrointestinal neoplasia-associated myofibroblasts can develop from bone marrow-derived cells following allogeneic stem cell transplantation.
Stem Cells
; 27(6): 1463-8, 2009 Jun.
Article
en En
| MEDLINE
| ID: mdl-19492298
ABSTRACT
This study characterized the contribution of bone marrow-derived cells to human neoplasia and the perineoplastic stroma. The Australasian Bone Marrow Transplant Recipient Registry was used to identify solid organ neoplasia that developed in female recipients of male allogeneic stem cell transplants. Eighteen suitable cases were identified including several skin cancers, two gastric cancers, and one rectal adenoma. Light microscopy, fluorescence and chromogenic in situ hybridization, and immunohistochemistry were performed to determine the nature and origin of the neoplastic and stromal cells. In contrast to recent reports, donor-derived neoplastic cells were not detected. Bone marrow-derived neoplasia-associated myofibroblasts, however, were identified in the rectal adenoma and in a gastric cancer. Bone marrow-derived cells can generate myofibroblasts in the setting of human gastrointestinal neoplasia.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias Primarias Secundarias
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Trasplante de Células Madre Hematopoyéticas
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Fibroblastos
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Neoplasias Gastrointestinales
Tipo de estudio:
Risk_factors_studies
Límite:
Female
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Humans
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Male
Idioma:
En
Revista:
Stem Cells
Año:
2009
Tipo del documento:
Article
País de afiliación:
Australia