Lymphoplasmacytic lymphoma with IgA hypergammaglobulinemia and liver involvement.
J Med Assoc Thai
; 92 Suppl 3: S65-8, 2009 Jun.
Article
en En
| MEDLINE
| ID: mdl-19702069
ABSTRACT
BACKGROUND:
Lymphoplasmacytic lymphoma (LPL) is a low grade lymphoma. Most cases are Waldenstorm macroglobulinemia which has IgM hypergammaglobulinemia. Lymphoplasmacytic lymphoma with IgA hypergammaglobulinemia is less than 5%. Liver involvement was reported in 20%. However this disease has been found to be mostly presented with lymphadenopathy and hypergammaglobulinemia. CASE REPORT We present a forty-year-old woman with anemia, renal insufficiency and abnormal liver function test. Liver biopsy showed atypical clonal B-cell lymphoproliferation, small cells with prominent plasmacytic differentiation. Serum protein electrophoresis showed monoclonal gammopathy which was IgA. Rituximab, fludarabine and cyclophosphamide were given and resulting in partial response.CONCLUSION:
The presentation of LPL can mimic multiple myeloma (anemia, renal failure and monoclonal gammopathy). Definite histological and immunological technique should be done to confirm the diagnosis.
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Bases de datos:
MEDLINE
Asunto principal:
Inmunoglobulina A
/
Macroglobulinemia de Waldenström
/
Hipergammaglobulinemia
/
Hepatopatías
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Med Assoc Thai
Año:
2009
Tipo del documento:
Article
País de afiliación:
Tailandia