Effect of carperitide on plasma adiponectin levels in acute decompensated heart failure patients with diabetes mellitus.
Circ J
; 73(12): 2264-9, 2009 Dec.
Article
en En
| MEDLINE
| ID: mdl-19797823
ABSTRACT
BACKGROUND:
It is reported that adiponectin has a cardioprotective effect and is decreased in type 2 diabetes mellitus (DM). METHODS ANDRESULTS:
The effect of carperitide (atrial natriuretic peptide ANP) on plasma adiponectin levels was evaluated in acute decompensated heart failure (ADHF) patients with and without DM. In 47 patients (DM n=11) who were admitted with ADHF, blood samples were collected before and 7 days after administration of carperitide. The plasma levels of ANP, brain natriuretic peptide (BNP), aldosterone and adiponectin were measured. Plasma adiponectin levels were significantly increased (17.6 +/-1.5 to 19.6 +/-1.8 microg/ml, P=0.0003) concomitant with the increase in ANP and decrease in BNP 7 days after carperitide infusion. Although adiponectin levels before treatment were slightly lower in ADHF patients with DM, the % increase in adiponectin levels was significantly greater in ADHF patients with DM than in those without DM (26.7 vs 6.6%, P=0.007). In the stepwise multivariate analyses, a higher plasma aldosterone levels before treatment (P=0.04) and DM (P=0.01) were significant independent predictors of a greater % increase in adiponectin levels after treatment with carperitide.CONCLUSIONS:
Carperitide infusion increases the plasma adiponectin level, especially in ADHF patients with DM.
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Bases de datos:
MEDLINE
Asunto principal:
Fármacos Cardiovasculares
/
Factor Natriurético Atrial
/
Complicaciones de la Diabetes
/
Insuficiencia Cardíaca
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Circ J
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Japón