Antigen specificity determines the pro- or antitumoral nature of CD8+ T cells.
J Immunol
; 184(2): 607-14, 2010 Jan 15.
Article
en En
| MEDLINE
| ID: mdl-20007540
ABSTRACT
Although CD8+ T cells are usually considered antitumoral, several recent studies report that the cells can also promote tumor progression. Using the melanoma cell line B16 as a murine model of pulmonary metastasis, we examined whether the pro- versus antitumoral effects of CD8+ T cells relate to their Ag specificity. Results of the study indicate that although CD8+ T cells specific for tumor Ags promote tumor rejection, CD8+ T cells specific for unrelated Ags promote tumor progression. We found the effect to be partly attributable to CD8+ T cells dampening effective antitumor NK cell responses. Notably, activation of CD8+ T cell responses by an unrelated stimulus, in this case infection with influenza virus, increased the number of pulmonary tumor nodules. These data provide a rationale for previously unexplained data identifying contrasting roles for CD8+ T cells in tumor progression.
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Bases de datos:
MEDLINE
Asunto principal:
Linfocitos T CD8-positivos
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Especificidad del Receptor de Antígeno de Linfocitos T
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Melanoma
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Antígenos
Límite:
Animals
Idioma:
En
Revista:
J Immunol
Año:
2010
Tipo del documento:
Article
País de afiliación:
Reino Unido