Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs.
Bioorg Med Chem Lett
; 20(5): 1783-6, 2010 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-20117930
ABSTRACT
The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs for further therapeutic development against the hepatitis B virus (HBV).
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Antivirales
/
Profármacos
/
Virus de la Hepatitis B
/
Hepatitis B
/
Nucleótidos
Límite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos