Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on stillbirths and on early and late neonatal mortality.
Food Nutr Bull
; 30(4 Suppl): S547-55, 2009 Dec.
Article
en En
| MEDLINE
| ID: mdl-20120796
ABSTRACT
BACKGROUND:
Multiple micronutrient deficiencies are common among women in low-income countries and may adversely affect pregnancy outcomes.OBJECTIVE:
To conduct a meta-analysis of the effects on stillbirths and on early and late neonatal mortality of supplementation during pregnancy with multiple micronutrients compared with iron-folic acid in recent randomized, controlled trials.METHODS:
Twelve randomized, controlled trials were included in the analysis (Bangladesh; Burkina Faso; China; Guinea-Bissau; Indramayu and Lombok, Indonesia; Mexico; Sarlahi and Janakur, Nepal; Niger; Pakistan; and Zimbabwe), all providing approximately 1 recommended dietary allowance (RDA) of multiple micronutrients or iron-folic acid to presumed HIV-negative women.RESULTS:
Supplementation providing approximately I RDA of multiple micronutrients did not decrease the risk of stillbirth (OR = 1.01; 95% CI, 0.88 to 1.16), early neonatal mortality (OR = 1.23; 95% CI, 0.95 to 1.59), late neonatal mortality (OR = 0.94; 95% CI, 0.73 to 1.23), or perinatal mortality (OR = 1.11; 95% CI, 0.93 to 1.33).CONCLUSIONS:
Our meta-analysis provides consistent evidence that supplementation providing approximately 1 RDA of multiple micronutrients during pregnancy does not result in any reduction in stillbirths or in early or late neonatal deaths compared with iron-folic acid alone.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Resultado del Embarazo
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Mortalidad Infantil
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Micronutrientes
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Suplementos Dietéticos
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Fenómenos Fisiologicos Nutricionales Maternos
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Países en Desarrollo
Tipo de estudio:
Clinical_trials
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Systematic_reviews
Límite:
Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Revista:
Food Nutr Bull
Año:
2009
Tipo del documento:
Article
País de afiliación:
Reino Unido