Slow switchover from host RNA synthesis to bacteriophage RNA synthesis after infection of Escherichia coli with a T4 mutant defective in the bacteriophage T4-induced unfolding of the host nucleoid.
J Virol
; 24(3): 775-85, 1977 Dec.
Article
en En
| MEDLINE
| ID: mdl-201776
ABSTRACT
Most, if not all, host RNA synthesis was shut off after infection of Escherichia coli strain B/5 with a bacteriophage T4 multiple mutant defective in the abilities to induce (i) unfolding of the host nucleoid (unf-), (ii) nuclear disruption (ndd-), and (iii) host DNA degradation (denA-, denB-). The shutoff of host RNA synthesis and turn-on of phage RNA synthesis were slower after infection of E. coli with unf- phage than after infection with unf+ phage. This delay in the switchover from host RNA synthesis to phage RNA synthesis in unf- infections did not result in a measurable delay in the onset of nuclear disruption, deoxyribonucleoside monophosphate kinase synthesis, or DNA synthesis. unf39 did not complement alc (allows late transcription on cytosine-containing DNA) mutants, supporting the proposal of Sirotkin et al. [Nature (London) 26528-32, 1977] that alc and unf are possibly the same gene.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
ARN Bacteriano
/
ARN Viral
/
Colifagos
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Escherichia coli
/
Genes Virales
Idioma:
En
Revista:
J Virol
Año:
1977
Tipo del documento:
Article