[A naturalistic study comparing two initial duloxetine dosing strategies in a clinical "real world" setting]. / Studio naturalistico di confronto tra due strategie di dosaggio iniziale di duloxetina in un contesto clinico "real world".
Riv Psichiatr
; 44(6): 384-92, 2009.
Article
en It
| MEDLINE
| ID: mdl-20218217
ABSTRACT
UNLABELLED AIMS. To compare, in a "real world" setting, the efficacy and tolerability of two initial duloxetine starting doses 30 mg once daily (q.d.) for 1 week, followed by escalation to 60 mg q.d. versus 60 mg q.d. without titolation, evaluating expecially the effects on sexual dysfunction. METHODS:
The sample is constituted by outpatients meeting diagnostic criteria for mild-severe (HAMD17 > or =24 and CGI-S > or =4) Major Depressive Episode as defined by DSM-IV-TR (Diagnostic and Statistic Manual for Mental Disorder, Fourth Edition-Text Revision), based on the Structured Clinical Interview for DSM-IV-TR (Mini International Neuropsychiatric Interview, MINI). The study design planned an initial evaluation and 4 follow-up visits; at each visit the following scales were administered Hamilton Rating Scale for Depression (HAMD17) and Anxiety (HAMA), Clinical Global Impression Severity Scale (CGI-S) for severity evaluation and Arizona Sexual Experience Scale (ASEX) for sexual disfunction evaluation.RESULTS:
Both of the groups showed 90% of response (> or = 50% reduction in a patient's HAMD17 total score from baseline) within 2 months of follow-up. 50% of patients receiving a 30 mg q.d. starting dose achieved a HAMD17 total score < or =7 versus 40% of 60 mg q.d. treating group. None showed relapses during the study. After the first treatment month, the 60 mg q.d. receiving group showed a statistical significative amelioration of sexual function (Mann-Whitney test p=0,02).CONCLUSIONS:
Our naturalistic "real world" study results confirm previous duloxetine tolerability and efficacy findings suggesting a 60 mg q.d. after meal duloxetine somministration without titolation.
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Bases de datos:
MEDLINE
Asunto principal:
Tiofenos
/
Depresión
/
Antidepresivos
Tipo de estudio:
Guideline
/
Qualitative_research
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
It
Revista:
Riv Psichiatr
Año:
2009
Tipo del documento:
Article