Altered regional brain morphology in patients with chronic facial pain.
Headache
; 50(8): 1278-85, 2010 Sep.
Article
en En
| MEDLINE
| ID: mdl-20236343
ABSTRACT
BACKGROUND:
Persistent idiopathic facial pain (PIFP) is defined as a persistent, unilateral facial pain, not associated with sensory loss or other physical signs and with no obvious structural abnormalities that would sufficiently explain pain experience.OBJECTIVE:
We were interested whether there is evidence of altered brain morphology in patients with PIFP as it has been described in other chronic pain conditions.METHODS:
Using voxel-based morphometry we investigated regional gray matter volume in 11 PIFP patients and 11 age- and sex-matched healthy controls. Furthermore we calculated lateralization indices (LI) to investigate differences in interhemispheric gray matter asymmetries.RESULTS:
We report a decrease in gray matter volume in the left anterior cingulate gyrus and left temporo-insular region, as well as in the left and right sensory-motor area, projecting to the representational area of the face. Analyses of LI values demonstrated an increased rightward asymmetry in the middle-anterior insular cortex in patients in comparison with healthy controls.CONCLUSION:
Our data support previous findings showing that chronic pain states are display-altered brain morphology in brain regions know to be part of the pain system.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Encéfalo
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Neuralgia Facial
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Headache
Año:
2010
Tipo del documento:
Article
País de afiliación:
Alemania