Interleukin 1 beta (IL1B) gene polymorphisms are not associated with gastric carcinogenesis in Germany.
Anticancer Res
; 30(2): 505-11, 2010 Feb.
Article
en En
| MEDLINE
| ID: mdl-20332462
ABSTRACT
BACKGROUND:
Polymorphisms of interleukin-1 beta gene (IL1B-511C>T) are considered as risk factor for gastric carcinogenesis, but conflicting data have been reported recently. PATIENTS ANDMETHODS:
The distribution of the four major IL1B variants (IL1B-3737C>T, -1464G>C, - 511C>T, -31T>C) were analyzed in 116 and 142 patients with gastric cancer and 'high risk gastritis', respectively, as well as 94 healthy controls.RESULTS:
While identified frequencies of genotypes, haplotypes and haplotype pairs corresponded to those of other studies in Caucasians, none were significantly associated with the presence of gastric cancer or premalignant alterations.CONCLUSION:
None of the four major polymorphisms is individually or in its haplotype configuration linked to the development of GC in this Caucasian population in Germany.
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Bases de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Neoplasias Gástricas
/
Interleucina-1beta
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Anticancer Res
Año:
2010
Tipo del documento:
Article
País de afiliación:
Alemania