Caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling.
J Biol Chem
; 285(26): 19921-6, 2010 Jun 25.
Article
en En
| MEDLINE
| ID: mdl-20385562
Caspase activating and recruitment domain 8 (CARD8) has been implicated as a co-regulator of several pro-inflammatory and apoptotic signaling pathways. In the present study, we demonstrate a specific modulation of NOD2-induced signaling by CARD8 in intestinal epithelial cells. We show that CARD8 physically interacts with NOD2 and inhibits nodosome assembly and subsequent signaling upon muramyl-dipeptide stimulation. Furthermore, CARD8 inhibits the direct bactericidal effect of NOD2 against intracellular infection by Listeria monocytogenes. Thus, CARD8 represents a novel molecular switch involved in the endogenous regulation of NOD2-dependent inflammatory processes in epithelial cells.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Transducción de Señal
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Colon
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Proteínas Adaptadoras de Señalización CARD
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Proteína Adaptadora de Señalización NOD2
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Proteínas de Neoplasias
Idioma:
En
Revista:
J Biol Chem
Año:
2010
Tipo del documento:
Article
País de afiliación:
Alemania