Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 protease.
Bioorg Med Chem Lett
; 20(12): 3550-6, 2010 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-20493689
We have designed and synthesized a novel series of alpha-amino cyclic boronates and incorporated them successfully in several acyclic templates at the P1 position. These compounds are inhibitors of the HCV NS3 serine protease, and structural studies show that they inhibit the NS3 protease by trapping the Ser-139 hydroxyl group in the active site. Synthetic methodologies and SARs of this series of compounds are described.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ácidos Borónicos
/
Proteínas no Estructurales Virales
/
Hepacivirus
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos