[Progress on Sp1-like and Krüppel-like factors].
Yi Chuan
; 32(6): 531-8, 2010 Jun.
Article
en Zh
| MEDLINE
| ID: mdl-20566455
ABSTRACT
Sp1-like and Krüppel-like factors (Sp1/KLFs) are a family of zinc-finger proteins that are important components of transcriptional machinery in eukaryotic cells. Sp1/KLFs have highly conserved DNA binding domains at the carboxyl terminus that have three tandem zinc-finger motifs. Their amino terminal regions vary greatly and contain transcription regulatory domains that interact with co-regulators. By regulating the expression of a large number of genes containing GC-rich or CACCC promoters in a tissue-, cell- and developmental stage-specific manner, Sp1/KLFs may be involved in many biological processes, including cell proliferation, differentiation, apoptosis and neoplastic transformation. In this article, we reviewed the structure, molecular mechanisms and biological functions of Sp1/KLFs.
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Bases de datos:
MEDLINE
Asunto principal:
Factor de Transcripción Sp1
/
Factores de Transcripción de Tipo Kruppel
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Yi Chuan
Asunto de la revista:
GENETICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
China