A decrease in gamma-synuclein expression within the nucleus accumbens increases cocaine intravenous self-administration in the rat.
Addict Biol
; 16(1): 120-3, 2011 Jan.
Article
en En
| MEDLINE
| ID: mdl-20579003
ABSTRACT
Except as a marker of cancer progression, gamma-synuclein (GSyn) had received little attention. Recent data showed however that GSyn modulates cocaine-induced locomotor effects, suggesting that it could also play a role in cocaine reinforcing effects. In the rat, siRNAs targeting GSyn expression were injected in the nucleus accumbens and cocaine reinforcing effects were evaluated by means of intravenous self-administration. A dose-response curve was followed by procedures of progressive ratio, extinction, cocaine- and cue-induced reinstatements. Decrease of GSyn expression increased self-administration over a large range of doses. This effect was associated with an increase in cocaine-induced reinstatement. The present data reveal that GSyn exert a specific negative control on cocaine-induced reinforcing and incentive effects.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Expresión Génica
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Abuso de Sustancias por Vía Intravenosa
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Trastornos Relacionados con Cocaína
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Gamma-Sinucleína
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Núcleo Accumbens
Límite:
Animals
Idioma:
En
Revista:
Addict Biol
Asunto de la revista:
TRANSTORNOS RELACIONADOS COM SUBSTANCIAS
Año:
2011
Tipo del documento:
Article
País de afiliación:
Suiza