Effect of Hemidesmus indicus on ischemia-reperfusion injury in the isolated rat heart.
Pharm Biol
; 48(6): 611-4, 2010 Jun.
Article
en En
| MEDLINE
| ID: mdl-20645732
ABSTRACT
The root extract of Hemidesmus indicus (Linn.) R. Br. (Asclepiadaceae) (HI) was studied for its cardioprotective effect in Langendorff-perfused rat hearts. HI was perfused for 15 min at a concentration of 0.09 g/L prior to 30 min global ischemia/120 min reperfusion (I/R). Recovery of functional parameters, reperfusion arrhythmias, and infarct size (TTC staining) served as the end-points. After 15 min of perfusion with HI, the left ventricular developed pressure (LVdevP) and HR (heart rate) were not altered significantly (p>0.05), as compared with the pre-drug values. During R, HI showed a significantly higher (p<0.05) recovery of LVdevP at nearly all time points. The recovery of maximal rate of pressure development (+dP/dtmax) and left ventricular end-diastolic pressure (LVEDP) at 40 min of R were significantly better than in non-treated controls. There was also a significant reduction in the total number of ventricular premature beats (VPB) and duration of ventricular tachycardia (VT). HI can protect ischemic myocardium against contractile dysfunction and reperfusion-induced arrhythmias and reduce the extent of irreversible tissue damage following I/R in rat hearts.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
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Cardiotónicos
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Daño por Reperfusión Miocárdica
/
Hemidesmus
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Pharm Biol
Año:
2010
Tipo del documento:
Article
País de afiliación:
Eslovaquia