CCL18 in peritoneal dialysis patients and encapsulating peritoneal sclerosis.
Eur J Clin Invest
; 40(12): 1067-73, 2010 Dec.
Article
en En
| MEDLINE
| ID: mdl-20695883
ABSTRACT
BACKGROUND:
Peritoneal fibrosis manifests clinically as membrane failure or encapsulating peritoneal sclerosis (EPS). There are no clinical or biochemical tests to determine the rate of progression of peritoneal fibrosis. CCL18/pulmonary and activation-regulated chemokine (PARC) is profibrotic and stimulates collagen production independent of the effect of transforming growth factor beta. This has not been studied in peritoneal dialysis (PD) patients. MATERIALS ANDMETHODS:
We have prospectively studied 106 patients, free from infection/recent peritonitis. A high concentration of CCL18 was discovered by multiplex antibody arrays and quantified by ELISA. Serum and dialysate levels were examined for their prognostic values.RESULTS:
By multiple regression analysis, dialysate CCL18 (6·76 ± 0·66 µg 4 h⻹) correlated with increasing membrane transport status (TS) (P < 0·0001) and total glucose exposure/24 h (P = 0·033). Serum CCL18 correlated with high TS (P = 0·0001) and duration of PD (P = 0·001). After 12 months of follow-up, 57 patients remained on PD while 12 patients were transferred to haemodialysis (HD) and seven developed EPS. Patients who subsequently developed EPS had higher baseline dialysate CCL18 (11·5 ± 3·6 µg 4 h⻹ vs. 5·6 ± 0·82 µg 4 h⻹, P = 0·03) and serum CCL18 (156·9 ± 12·8 ng mL⻹ vs. 124·8 ± 12·2 ng mL⻹, P = 0·02) compared with the stable PD group.CONCLUSION:
This is the first report of high levels of CCL18 in the spent dialysate and serum from long-term PD patients. These levels correlated with dysfunction of peritoneal membrane transport status, therefore following CCL18 in a longitudinal study may be of interest.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Diálisis Peritoneal Ambulatoria Continua
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Quimiocinas CC
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Fibrosis Peritoneal
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
Límite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur J Clin Invest
Año:
2010
Tipo del documento:
Article
País de afiliación:
Reino Unido