Influence of solubilizing environments on membrane protein structures.
Trends Biochem Sci
; 36(2): 117-25, 2011 Feb.
Article
en En
| MEDLINE
| ID: mdl-20724162
ABSTRACT
Membrane protein structures are stabilized by weak interactions and are influenced by additional interactions with the solubilizing environment. Structures of influenza virus A M2 protein, a proven drug target, have been determined in three different environments, thus providing a unique opportunity to assess environmental influences. Structures determined in detergents and detergent micelles can have notable differences from those determined in lipid bilayers. These differences make it imperative to validate membrane protein structures.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Proteínas de la Matriz Viral
/
Proteínas de la Membrana
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos