Newborn TSH concentration and its association with cognitive development in healthy boys.
Eur J Endocrinol
; 163(6): 901-9, 2010 Dec.
Article
en En
| MEDLINE
| ID: mdl-20829366
ABSTRACT
OBJECTIVE:
An association between thyroid function during pregnancy or infancy and neurodevelopment in children has been demonstrated. We aimed to investigate whether newborn TSH concentrations are related to subsequent neurocognitive development.DESIGN:
We conducted a longitudinal study on 178 children from a general population birth cohort in Granada (Spain) born in 2000-2002.METHODS:
TSH concentrations were measured in umbilical cord blood, and cognitive functions were assessed at 4 years of age using the McCarthy's scales of children's abilities (MSCA). Organochlorine (OC) compound concentrations and the combined oestrogenicity (total effective xeno-oestrogenic burden (TEXB)) were also determined in the placentae.RESULTS:
Mean newborn TSH was 3.55 âmU/l (range=0.24-17 mU/l). In multivariate regression analyses, adjusting for maternal and child characteristics, higher newborn TSH concentrations showed a decrease of 3.51 and 3.15 points on the MSCA general cognitive and executive function scores respectively and were associated with a higher risk of scoring below the 20th percentile (P20) on the quantitative score (odds ratio (OR)=2.64). Children with TSH in the upper quartile (4.19-17.0 mU/l) were at higher risk of scoringCONCLUSIONS:
Newborn thyroid hormone status expressed by TSH in cord blood may adversely affect later cognitive function. A more thorough screening for neonatal thyroid deficiency is warranted.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Recién Nacido
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Tirotropina
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Cognición
Tipo de estudio:
Clinical_trials
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Observational_studies
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Risk_factors_studies
Límite:
Child, preschool
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Female
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Humans
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Male
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Pregnancy
Idioma:
En
Revista:
Eur J Endocrinol
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
España