Copper complex of a pyridine-modified poly(amidoamine) dendrimer as a chemical nuclease: synthetic and catalytic study.
Nanomedicine
; 7(3): 273-6, 2011 Jun.
Article
en En
| MEDLINE
| ID: mdl-21059403
ABSTRACT
[Cu(Y)((G2-6)-dendri-PAMAM-(Py)(n))](2Y+) complexes (3) were prepared, and their ability to generate oxygen radical anions was investigated. The maximum catalytic efficiency (k'(cat)/K(M)) was found to be 0.32 min(-1)·µM(-1), and a positive dendritic effect was observed. The saturated kinetics revealed that the improved catalytic efficiency resulted from an enhanced binding affinity toward molecular oxygen. FROM THE CLINICAL EDITOR In this basic science study, the oxygen radical anion generating ability of specific copper complex of a pyridine-modified poly(amidoamine) dendrimer was investigated and reported in details.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Poliaminas
/
Piridinas
/
Cobre
/
Desoxirribonucleasas
/
Dendrímeros
Idioma:
En
Revista:
Nanomedicine
Asunto de la revista:
BIOTECNOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Taiwán