A randomised trial comparing sufentanil versus remifentanil for laparoscopic gastroplasty in the morbidly obese patient.
Eur J Anaesthesiol
; 28(2): 120-4, 2011 Feb.
Article
en En
| MEDLINE
| ID: mdl-21088598
ABSTRACT
BACKGROUND AND OBJECTIVE:
This prospective, randomised double-blind study compared the effects of target control infusion (TCI) of sufentanil and remifentanil on the quality of recovery and post-operative pain control in morbidly obese patients undergoing laparoscopic gastroplasty.METHODS:
Following institutional Ethics Committee approval and written informed consent, 100 morbidly obese patients were randomised to receive either TCI sufentanil (0.3 ng ml⻹; S-group; N = 50) or TCI remifentanil (3 ng ml⻹; R-group; N = 50) in combination with desflurane (O2/air mixture FiO2, 50%). Quality of recovery was estimated by means of the modified Aldrete score and by the ability to perform psychomotor tests with the same competence post-operatively as pre-operatively. Post-operative pain was evaluated by the quantity of piritramide needed to achieve a visual analogue scale (VAS) less than 3. Statistical analysis was performed using an unpaired Student's t-test, Mann-Whitney U-test and χ² test, as appropriate.RESULTS:
Patient and surgical characteristics were similar among groups. In the R-group, time to extubation was significantly shorter, but VAS significantly higher than that in the S-group (P < 0.01). Quality of recovery and duration of post-anaesthesia care unit stay were comparable between groups (S-group 119 ± 27 min and R-group 119 ± 35 min). Piritramide consumption during the first 4 post-operative hours was higher in the R-group than in the S-group [S-group (median, range) 11.5 mg, 5.5-16.0; R-group 18.0 mg, 14-22, P < 0.01], but not later on.CONCLUSION:
In the conditions of the present study, although TCI sufentanil resulted in slower awakening than TCI remifentanil, it was associated with a better quality of recovery.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Dolor Postoperatorio
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Piperidinas
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Obesidad Mórbida
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Gastroplastia
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Sufentanilo
Tipo de estudio:
Clinical_trials
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur J Anaesthesiol
Asunto de la revista:
ANESTESIOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Países Bajos