Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication.
Bioorg Med Chem Lett
; 21(1): 262-6, 2011 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-21109432
An early lead from the AMD070 program was optimized and a structure-activity relationship was developed for a novel series of heterocyclic containing compounds. Potent CXCR4 antagonists were identified based on anti-HIV-1 activity and Ca(2+) flux inhibition that displayed good pharmacokinetics in rat and dog.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Replicación Viral
/
VIH-1
/
Fármacos Anti-VIH
/
Receptores CXCR4
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos