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microRNA-92a promotes lymph node metastasis of human esophageal squamous cell carcinoma via E-cadherin.
Chen, Zhao-li; Zhao, Xiao-hong; Wang, Ji-wen; Li, Bao-zhong; Wang, Zhen; Sun, Jian; Tan, Feng-wei; Ding, Da-peng; Xu, Xiao-hui; Zhou, Fang; Tan, Xiao-gang; Hang, Jie; Shi, Su-sheng; Feng, Xiao-li; He, Jie.
Afiliación
  • Chen ZL; Department of Thoracic Surgery, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China.
J Biol Chem ; 286(12): 10725-34, 2011 Mar 25.
Article en En | MEDLINE | ID: mdl-21148309
microRNAs (miRNAs) regulate gene expression at the post-transcriptional level and play important roles in tumor initiation and progression. Recently, we examined the global miRNA expression profile of esophageal squamous cell carcinoma (ESCC) and demonstrated that miR-92a was highly expressed in tumor tissues. In this study, we found that the up-regulation of miR-92a was significantly correlated with the status of lymph node metastasis and TNM stage in 107 ESCC patients. Moreover, the up-regulation of miR-92a was associated with poor survival of ESCC patients and might be used as an independent prognostic factor. Next, we investigated the role and mechanism of miR-92a in ESCC cells, and found that miR-92a modulated the migration and invasion but not apoptosis and proliferation of ESCC cells in vitro. We further demonstrated that miR-92a directly targeted the CDH1 3'-UTR and repressed the expression of CDH1, a tumor metastasis suppressor. In addition, restoring of miR-92a-resistant CDH1 expression in miR-92a-overexpression cells recovered the pro-metastasis activity of miR-92a. Taken together, we demonstrated that miR-92a promotes ESCC cell migration and invasion at least partially via suppression of CDH1 expression, and patients with up-regulated miR-92a are prone to lymph node metastasis and thus have poor prognosis.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ARN Neoplásico / Neoplasias Esofágicas / Carcinoma de Células Escamosas / Cadherinas / Regulación Neoplásica de la Expresión Génica / MicroARNs / Ganglios Linfáticos Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: J Biol Chem Año: 2011 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ARN Neoplásico / Neoplasias Esofágicas / Carcinoma de Células Escamosas / Cadherinas / Regulación Neoplásica de la Expresión Génica / MicroARNs / Ganglios Linfáticos Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: J Biol Chem Año: 2011 Tipo del documento: Article País de afiliación: China