Fluorine in medicinal chemistry: ß-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA.
Org Biomol Chem
; 9(5): 1328-31, 2011 Mar 07.
Article
en En
| MEDLINE
| ID: mdl-21221451
Comparative X-ray structure studies reveal that C-F bond incorporation into the peripheral pyrrolidine moieties of the G-quadruplex DNA binding ligand BSU6039 leads to a distinct pyrrolidine ring conformation, relative to the non-fluorinated analogue, and with a different binding mode involving reversal of the pyrrolidinium N(+)-H orientation.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Pirrolidinas
/
Acridinas
/
G-Cuádruplex
/
Flúor
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2011
Tipo del documento:
Article