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Fluorine in medicinal chemistry: ß-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA.
Campbell, Nancy H; Smith, Daniel L; Reszka, Anthony P; Neidle, Stephen; O'Hagan, David.
Afiliación
  • Campbell NH; The School of Pharmacy, University of London, 29-39 Brunswick Square, London, UK WC1N 1AX.
Org Biomol Chem ; 9(5): 1328-31, 2011 Mar 07.
Article en En | MEDLINE | ID: mdl-21221451
Comparative X-ray structure studies reveal that C-F bond incorporation into the peripheral pyrrolidine moieties of the G-quadruplex DNA binding ligand BSU6039 leads to a distinct pyrrolidine ring conformation, relative to the non-fluorinated analogue, and with a different binding mode involving reversal of the pyrrolidinium N(+)-H orientation.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pirrolidinas / Acridinas / G-Cuádruplex / Flúor Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2011 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pirrolidinas / Acridinas / G-Cuádruplex / Flúor Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2011 Tipo del documento: Article