Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.
Bioorg Med Chem Lett
; 21(5): 1414-8, 2011 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-21295470
A novel series of CXCR4 antagonists were identified based on the substantial redesign of AMD070. These compounds possessed potent anti-HIV-1 activity and showed excellent pharmacokinetics in rat and dog.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Replicación Viral
/
Diseño de Fármacos
/
VIH-1
/
Fármacos Anti-VIH
/
Receptores CXCR4
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos