The role of research in viral disease eradication and elimination programs: lessons for malaria eradication.
PLoS Med
; 8(1): e1000405, 2011 Jan 25.
Article
en En
| MEDLINE
| ID: mdl-21311582
ABSTRACT
By examining the role research has played in eradication or regional elimination initiatives for three viral diseases--smallpox, poliomyelitis, and measles--we derive nine cross-cutting lessons applicable to malaria eradication. In these initiatives, some types of research commenced as the programs began and proceeded in parallel. Basic laboratory, clinical, and field research all contributed notably to progress made in the viral programs. For each program, vaccine was the lynchpin intervention, but as the programs progressed, research was required to improve vaccine formulations, delivery methods, and immunization schedules. Surveillance was fundamental to all three programs, whilst polio eradication also required improved diagnostic methods to identify asymptomatic infections. Molecular characterization of pathogen isolates strengthened surveillance and allowed insights into the geographic source of infections and their spread. Anthropologic, sociologic, and behavioural research were needed to address cultural and religious beliefs to expand community acceptance. The last phases of elimination and eradication became increasingly difficult, as a nil incidence was approached. Any eradication initiative for malaria must incorporate flexible research agendas that can adapt to changing epidemiologic contingencies and allow planning for posteradication scenarios.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Investigación
/
Virosis
/
Control de Enfermedades Transmisibles
/
Malaria
Tipo de estudio:
Prognostic_studies
/
Screening_studies
Límite:
Animals
/
Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
PLoS Med
Asunto de la revista:
MEDICINA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos