Rare events in population genetics: stochastic tunneling in a two-locus model with recombination.
Phys Rev Lett
; 106(8): 088101, 2011 Feb 25.
Article
en En
| MEDLINE
| ID: mdl-21405603
ABSTRACT
We study the evolution of a population in a two-locus genotype space, in which the negative effects of two single mutations are overcompensated in a high-fitness double mutant. We discuss how the interplay of finite population size N and sexual recombination at rate r affects the escape times t(esc) to the double mutant. For small populations demographic noise generates massive fluctuations in t(esc). The mean escape time varies nonmonotonically with r, and grows exponentially as lnt(esc)â¼N(r-r(*))(3/2) beyond a critical value r(*).
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Bases de datos:
MEDLINE
Asunto principal:
Recombinación Genética
/
Sitios Genéticos
/
Modelos Genéticos
Idioma:
En
Revista:
Phys Rev Lett
Año:
2011
Tipo del documento:
Article
País de afiliación:
Alemania