Hyperbranched polycarbonate-based multimolecular micelle with enhanced stability and loading efficiency.
Macromol Rapid Commun
; 32(4): 390-6, 2011 Feb 16.
Article
en En
| MEDLINE
| ID: mdl-21433189
ABSTRACT
We herein develop a facile catalyst-free method to prepare hyperbranched hydroxyl-enriched aliphatic polycarbonate according to SCROP strategy. PEG-attached multiarm hyperbranched copolymer HEHDO-star-mPEG was further designed. It was found that HEHDO-star-mPEG can self-assemble into supramolecular multimolecular micelles in water. HEHDO-star-mPEG micelle showed excellent stability with respect to micellar size upon dilution, and displayed good cell-biocompatibility. An anticancer drug of doxorubicin with hydrogen-bonding functionality was incorporated into obtained micelles to establish a drug delivery system model. A high drug-loading content as well as sustained release pattern for HEHDO-star-mPEG based delivery system was achieved.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cemento de Policarboxilato
/
Polímeros
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Portadores de Fármacos
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Sistemas de Liberación de Medicamentos
Límite:
Humans
Idioma:
En
Revista:
Macromol Rapid Commun
Año:
2011
Tipo del documento:
Article
País de afiliación:
China