Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives: Part II.

Shanab, Karem; Schirmer, Eva; Wulz, Eva; Weissenbacher, Barbara; Lassnig, Sigrid; Slanz, Rita; Fösleitner, Germana; Holzer, Wolfgang; Spreitzer, Helmut; Schmidt, Peter; Aicher, Babette; Müller, Gilbert; Günther, Eckhard

Shanab, Karem; Schirmer, Eva; Wulz, Eva; Weissenbacher, Barbara; Lassnig, Sigrid; Slanz, Rita; Fösleitner, Germana; Holzer, Wolfgang; Spreitzer, Helmut; Schmidt, Peter; Aicher, Babette; Müller, Gilbert; Günther, Eckhard.

Afiliación

Shanab K; Department of Drug and Natural Product Synthesis, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.

Bioorg Med Chem Lett ; 21(10): 3117-21, 2011 May 15.

Article en En | MEDLINE | ID: mdl-21458262

ABSTRACT

ABSTRACT

A series of 6-azanaphthoquinone pyrrolo-annelated derivatives carrying different basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines with Mitoxantrone as reference compound. Cytotoxic effects and DNA intercalation behavior were investigated.

Asunto(s)

Antineoplásicos/síntesis química; Antineoplásicos/farmacología; Pirroles/síntesis química; Pirroles/farmacología; Antineoplásicos/química; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Estructura Molecular; Naftoquinonas/química; Pirroles/química; Relación Estructura-Actividad

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pirroles / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2011 Tipo del documento: Article País de afiliación: Austria

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