Sequential development of diffuse large B-cell lymphoma in a patient with angioimmunoblastic T-cell lymphoma.
Diagn Cytopathol
; 40(4): 346-51, 2012 Apr.
Article
en En
| MEDLINE
| ID: mdl-21472868
ABSTRACT
Lymphoma of different histologic type can occur in the same patient. Here, we describe a 64-year-old male patient with angioimmunoblastic T-cell lymphoma (AITL) who subsequently developed diffuse large B-cell lymphoma (DLBCL). At the time of initial diagnosis, histologic examination of a left inguinal lymph node of the patient and a monoclonal pattern of TCRß gene rearrangement showed typical features of AITL, and there was no evidence of a monoclonal B-cell population. Twenty-six months later, he had generalized lymphadenopathy and organs involvement by DLBCL. A monoclonal IgH gene rearrangement proved de novo development of secondary B-cell lymphoma and excluded relapse of a primary composite lymphoma. The in situ hybridization analysis showed Epstein-Barr-encoded RNA (EBER) sporadic positivity in sample collected from AITL but extensive positivity in the immunoblasts collected from DLBCL. Our observation supports the hypothesis that Epstein-Barr virus (EBV) is etiologically related to AITL in this case. Clonal expansion of EBV-associated DLBCL is a secondary event in AITL via EBV infection or reactivation.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Linfoma de Células T
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Linfoma de Células B Grandes Difuso
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Linfadenopatía Inmunoblástica
Límite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Diagn Cytopathol
Asunto de la revista:
PATOLOGIA
Año:
2012
Tipo del documento:
Article