[Inflammation, angiogenesis and epilepsy]. / Inflammation, angiogenèse et épilepsie.
Biol Aujourdhui
; 205(1): 33-41, 2011.
Article
en Fr
| MEDLINE
| ID: mdl-21501573
ABSTRACT
It is well admitted now that gliosis participates in epileptogenesis, particularly in symptomatic focal epilepsies, like temporal lobe epilepsy. Indeed, astrocytic and microglial activation was shown to release numerous inflammatory factors that modify neuronal excitability or contribute to neuronal loss. These redundant processes maintain chronic epilepsy. However, other sources of inflammation exist. Several studies pointed out the epileptogenicity of blood-brain barrier disruption due to the leakage of leukocytes and serum proteins, triggering inflammatory and immune responses which disturb the neuronal environment. Recently, it was proposed that peripheral inflammation plays a key-role in epilepsy, mainly mediated by circulating cytokines which promote leukocyte extravasation.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Epilepsia
/
Inflamación
/
Neovascularización Patológica
Límite:
Animals
/
Humans
Idioma:
Fr
Revista:
Biol Aujourdhui
Año:
2011
Tipo del documento:
Article
País de afiliación:
Francia