Passive immunization with Leptospira LPS-specific agglutinating but not non-agglutinating monoclonal antibodies protect guinea pigs from fatal pulmonary hemorrhages induced by serovar Copenhageni challenge.
Vaccine
; 29(27): 4431-4, 2011 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-21549788
Leptospira interrogans serovar Copenhageni causes pulmonary hemorrhages with respiratory failure, a major cause of death in leptospirosis patients. Protective immunity to Leptospira is known to correlate with the production of leptospiral lipopolysaccharide (L-LPS)-specific agglutinating antibodies. We generated L-LPS-specific mouse monoclonal antibodies (MAbs) and investigated if these MAbs can protect guinea pigs against fatal pulmonary hemorrhages caused by serovar Copenhageni. The MAbs L8H4 and L9B11 against 22kDa L-LPS agglutinated leptospires and completely protected guinea pigs from the development of fatal pulmonary hemorrhages by serovar Copenhageni, whereas the MAb L4C1 against 8kDa L-LPS neither agglutinated the bacteria nor protected the animals against the fatal pulmonary hemorrhages.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Lipopolisacáridos
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Inmunización Pasiva
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Hemorragia
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Leptospira interrogans
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Leptospirosis
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Enfermedades Pulmonares
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Anticuerpos Monoclonales
Límite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Vaccine
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos