Side chain SAR of bicyclic ß-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712.
Bioorg Med Chem Lett
; 21(14): 4267-70, 2011 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-21676616
ABSTRACT
The bridged monobactam ß-lactamase inhibitor MK-8712 (1) effectively inhibits class C ß-lactamases. Side chain N-alkylated and ring-opened analogs of 1 were prepared and evaluated for combination with imipenem to overcome class C ß-lactamase mediated resistance. Although some analogs were more potent inhibitors of AmpC, none exhibited better synergy with imipenem than 1.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Monobactamas
/
Inhibidores Enzimáticos
/
Inhibidores de beta-Lactamasas
/
Antibacterianos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos