Potential role of IL-13 in neuroprotection and cortical excitability regulation in multiple sclerosis.
Mult Scler
; 17(11): 1301-12, 2011 Nov.
Article
en En
| MEDLINE
| ID: mdl-21677024
ABSTRACT
BACKGROUND:
Inflammation triggers secondary neurodegeneration in multiple sclerosis (MS).OBJECTIVES:
It is unclear whether classical anti-inflammatory cytokines have the potential to interfere with synaptic transmission and neuronal survival in MS.METHODS:
Correlation analyses between cerebrospinal fluid (CSF) contents of anti-inflammatory cytokines and molecular, imaging, clinical, and neurophysiological measures of neuronal alterations were performed.RESULTS:
Our data suggest that interleukin-13 (IL-13) plays a neuroprotective role in MS brains. We found, in fact, that the levels of IL-13 in the CSF of MS patients were correlated with the contents of amyloid-ß(1-42). Correlations were also found between IL-13 and imaging indexes of axonal and neuronal integrity, such as the retinal nerve fibre layer thickness and the macular volume evaluated by optical coherence tomography. Furthermore, the levels of IL-13 were related to better performance in the low-contrast acuity test and Multiple Sclerosis Functional Composite scoring. Finally, by means of transcranial magnetic stimulation, we have shown that GABAA-mediated cortical inhibition was more pronounced in patients with high IL-13 levels in the CSF, as expected for a neuroprotective, anti-excitotoxic effect.CONCLUSIONS:
The present correlation study provides some evidence for the involvement of IL-13 in the modulation of neuronal integrity and synaptic function in patients with MS.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Interleucina-13
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Esclerosis Múltiple Recurrente-Remitente
/
Corteza Motora
/
Degeneración Nerviosa
/
Neuronas
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Límite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Mult Scler
Asunto de la revista:
NEUROLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Italia