Diagnosis of oral hairy leukoplakia by ultrastructural examination of exfoliative cytologic specimens.
Oral Surg Oral Med Oral Pathol
; 70(5): 613-8, 1990 Nov.
Article
en En
| MEDLINE
| ID: mdl-2172887
ABSTRACT
Lingual exfoliative cytologic specimens (scrapings) were obtained from 18 patients positive for human immunodeficiency virus with clinical oral hairy leukoplakia. Buccal mucosal scrapings were obtained from 12 of these patients. The specimens were processed for examination by transmission electron microscopy (TEM). Sixteen (89%) of the lingual specimens revealed infection of keratinocytes by herpes-type virus. There was no evidence of virus infection in the 12 buccal mucosal scrapings. Fungal hyphae were seen by TEM in 14 (78%) of the lingual scrapings and two (17%) of the buccal scrapings. One exfoliative specimen and two biopsy specimens were stained for Epstein-Barr virus DNA with a DNA probe. The demonstration of herpes-type virions by TEM in keratinocytes from a lesion clinically suspected to be hairy leukoplakia provides direct, objective diagnosis. Furthermore, use of exfoliative cytologic specimens provides a clinically simple, noninvasive technique.
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Bases de datos:
MEDLINE
Asunto principal:
Leucoplasia Bucal
/
Neoplasias de la Boca
Tipo de estudio:
Diagnostic_studies
/
Guideline
/
Prognostic_studies
Límite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Oral Surg Oral Med Oral Pathol
Año:
1990
Tipo del documento:
Article
País de afiliación:
Moldova