Cytotoxic triterpenoid saponins from Lysimachia clethroides.
J Nat Prod
; 74(10): 2128-36, 2011 Oct 28.
Article
en En
| MEDLINE
| ID: mdl-21928797
ABSTRACT
Seven oleanane-type triterpenoid saponins, named clethroidosides A-G (1-7), an ursane-type triterpenoid saponin, clethroidoside H (8), and six known saponins were isolated from the aerial parts of Lysimachia clethroides. The structures of the saponins were elucidated on the basis of physical data analysis (1D and 2D NMR, HR-ESIMS) and chemical evidence. The cytotoxic activities of compounds 1-14 were evaluated against five human tumor cell lines (HT-29, HePG2, BGC-823, A549, and A375). Compounds 3, 4, 6, and 11-13 exhibited moderate cytotoxic activity, with IC50 values of 0.75-2.62 µM, while compound 5 showed selective cytotoxic activity.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Saponinas
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Triterpenos
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Medicamentos Herbarios Chinos
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Primulaceae
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Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
J Nat Prod
Año:
2011
Tipo del documento:
Article