WAP domain proteins as modulators of mucosal immunity.
Biochem Soc Trans
; 39(5): 1409-15, 2011 Oct.
Article
en En
| MEDLINE
| ID: mdl-21936824
ABSTRACT
WAP (whey acidic protein) is an important whey protein present in milk of mammals. This protein has characteristic domains, rich in cysteine residues, called 4-DSC (four-disulfide core domain). Other proteins, mainly present at mucosal surfaces, have been shown to also possess these characteristic WAP-4-DSC domains. The present review will focus on two WAP-4-DSC containing proteins, namely SLPI (secretory leucocyte protease inhibitor) and trappin-2/elafin. Although first described as antiproteases able to inhibit in particular host neutrophil proteases [NE (neutrophil elastase), cathepsin-G and proteinase-3] and as such, able to limit maladaptive tissue damage during inflammation, it has become apparent that these molecules have a variety of other functions (direct antimicrobial activity, bacterial opsonization, induction of adaptive immune responses, promotion of tissue repair, etc.). After providing information about the 'classical' antiproteasic role of these molecules, we will discuss the evidence pertaining to their pleiotropic functions in inflammation and immunity.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Inmunidad Mucosa
/
Elafina
/
Inhibidor Secretorio de Peptidasas Leucocitarias
/
Proteínas de la Leche
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochem Soc Trans
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido