Spirocyclic acylphloroglucinol derivatives from Hypericum beanii.
Chem Pharm Bull (Tokyo)
; 59(10): 1250-3, 2011.
Article
en En
| MEDLINE
| ID: mdl-21963634
ABSTRACT
Four new acylphloroglucinols with an unusual 6/6/5 spirocyclic skeleton, hyperbeanols A-D (1-4), were isolated from the methanol extract of Hypericum beanii along with 16 known compounds. Their structures were established on the basis of spectroscopic and X-ray diffraction analysis. Hyperbeanols A-C were three stereoisomers different only at the relative configuration of C-4 and C-13, which were distinguished by the nuclear Overhauser effect spectroscopy (NOESY) spectroscopic data in combination with the single X-ray analysis of hyperbeanol A (1). The cytotoxic activity of hyperbeanols A-D against the cancer cell lines SK-BR-3, HL-60, SMMC-7721, PANC-1, MCF-7, and K562 was also evaluated.
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Bases de datos:
MEDLINE
Asunto principal:
Floroglucinol
/
Extractos Vegetales
/
Hypericum
/
Fitoterapia
/
Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Año:
2011
Tipo del documento:
Article