High resolution magnetic susceptibility mapping of the substantia nigra in Parkinson's disease.
J Magn Reson Imaging
; 35(1): 48-55, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-21987471
ABSTRACT
PURPOSE:
To determine if tissue magnetic susceptibility is a more direct marker of tissue iron content than other MR markers of iron. This study presents the first quantitative, in vivo measurements of the susceptibility of the substantia nigra in patients with Parkinson's disease. MATERIALS ANDMETHODS:
Nine patients and 11 controls were studied at 7 Tesla. Susceptibility maps were created by inverting the filtered phase maps associated with T2* weighted images.RESULTS:
On average, patients showed an increase in susceptibility of the pars compacta compared with controls, which correlates with the predicted increase in brain iron in Parkinson's disease. A rostral-caudal gradient in susceptibility was also observed in controls and patients.CONCLUSION:
Susceptibility mapping may provide a new tool for studying the development of Parkinson's disease.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
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Mapeo Encefálico
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Sustancia Negra
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Imagen por Resonancia Magnética
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Hierro
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Magn Reson Imaging
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2012
Tipo del documento:
Article
País de afiliación:
Reino Unido