Synthesis of substituted isoquinolines via Pd-catalyzed cross-coupling approaches.
Org Lett
; 13(23): 6180-3, 2011 Dec 02.
Article
en En
| MEDLINE
| ID: mdl-22066469
ABSTRACT
Palladium complexes incorporating ligands based on a 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phosphaadamantanyl scaffold were used to catalyze the arylation of ethyl cyanoacetate, malononitrile, and various ketones. The products from these reactions can be elaborated to substituted ß-arylethylamines and used in microwave-assisted Pictet-Spengler reactions. The protocol developed is suitable for the synthesis of libraries of substituted isoquinolines.
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MEDLINE
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2011
Tipo del documento:
Article